Mona Gray is a 20-year-old loner who, as a child, turned to math for salvation after her father became ill. As an adult, Mona now teaches the subject and must help her students through their own crises.

n New York, the immature family man Leo Vidales is a successful businessman, owner of the Underlandish, a successful website of digital games and married to Dr. Ellen Vidales, a dedicated surgeon of the emergency room of a hospital. They have a daughter, Jackie, who is an intelligent girl that is raised by her nanny, the Filipino Gloria that spends more time with her than Ellen. Gloria has two sons in Philippine that miss her. When Leo need to travel to Singapore with his partner Bob (Tom McCarthy) to sign a millionaire contract with investors, Ellen operates on a boy stabbed in the stomach by his own mother and she feels connected to the boy and rethinks her relationship with Jackie. Meanwhile Leo is bored waiting for the negotiation of Bob with the investors and he decides to travel to Bangkok and lodges in a rustic cottage on the seashore. Leo meets the young prostitute and mother Cookie and he has one night stand with her...

Two down on their luck childhood friends struggle to figure out their lives. Ray a drummer in a rock and roll band, and Owen an aspiring film maker spend most of their time working menial jobs and drinking. When Owen's fiancé Lynn breaks off their engagement he finds himself spiraling, and allows Ray to come along with him to a two bit film festival he has been invited to in Kansas. There Owen makes several attempts to patch up his relationship, while Ray scams them into a deluxe suite at the local Four Seasons hotel by posing as Wally Shawn's son (who happens to be receiving a lifetime achievement award) and generally causes a major ruckus. By the end, Owen decides to make some changes in their relationship and in his life.

An international soccer star is on his way to sign a multi-million dollar contract when a series of events unfold that bring his career to an abrupt end. A beautiful waitress, struggling to make it in New York City, discovers something about herself that she's unprepared for. In one irreversible moment, their lives are turned upside down... until a simple gesture of kindness brings them both together, turning an ordinary day to an unforgettable experience.